Dr. Brahm Segal appointed to NextCure Scientific Advisory Board; NextCure and Roswell Park Shared Nonclinical Data on the Impact of NC410 Blockade on Neutrophil-mediated T Cell Suppression at the 24th Translational Research Cancer Centers Consortium Annua
These data support further investigation into specific roles of LAIR-1 engagement on neutrophils and T cells in the TME and mechanisms by which NC410 can rescue T cell responsiveness.
“Dr. Segal and members of his lab have applied their expertise of the innate immune system to delineate mechanisms by which neutrophils suppress T cells in the TME and contributes to overall immunosuppression,” said
Highlights of the data presented include:
- Normal circulating neutrophils have minimal surface LAIR-1 expression, while exposure to ascites fluid supernatants from patients with newly diagnosed ovarian cancer induced rapid-onset and sustained expression of LAIR-1.
- T cells constitutively express surface LAIR-1, and LAIR-1 expression in ascites T cells (TALs) was either similar to or increased compared to circulating T cells in a cohort of patients with newly diagnosed ovarian cancer.
- NC410 successfully abrogated neutrophil-mediated T cell suppression in the TME. When exposed to the combination of circulating neutrophils and ovarian cancer ascites fluid supernatants, stimulated circulating T cells have markedly suppressed proliferation; however, T cell proliferation was rescued with the addition of NC410. In separate studies of T cells incubated with ascites fluid alone, NC410 partially rescued stimulated IL-2 production.
NC410 is a first-in-class immunomedicine designed to block immune suppression mediated by LAIR-1, an immunomodulatory receptor expressed on T cells and myeloid cells, including dendritic cells, a type of antigen presenting cell. In preclinical research, it has been shown that LAIR-1 inhibits T cell function and myeloid activity. In preclinical studies, NC410 blocks the negative effects of LAIR-1 and promotes T cell function and myeloid cell activity. NextCure believes NC410 has the potential to treat multiple cancer types.
About NextCure, Inc.
NextCure is a clinical-stage biopharmaceutical company committed to discovering and developing novel, first-in-class immunomedicines to treat cancer and other immune-related diseases. Through our proprietary FIND-IO™ platform, we study various immune cells to discover and understand targets and structural components of immune cells and their functional impact in order to develop immunomedicines. Our initial focus is to bring hope and new treatments to patients who do not respond to current cancer therapies, patients whose cancer progresses despite treatment and patients with cancer types not adequately addressed by available therapies. http://www.nextcure.com
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