NextCure to Present Trial in Progress Poster for NC525 at the 2022 American Society of Hematology (ASH) Annual Meeting
“At last year’s ASH conference, we shared promising preclinical data on NC525 demonstrating that targeting LAIR-1 on AML leukemic stem cells (LSCs) and blast cells specifically eradicates both the AML LSCs and blast cells, while preserving healthy hematopoietic stem and progenitor cells in pre-clinical models,” said
Acute myeloid leukemia (AML) remains incurable for most patients with current therapies. LAIR-1 is an immune inhibitory receptor that is present on most immune cell subsets. However, high expression of LAIR-1 is seen on leukemic stem cells and blast cells, whereas LAIR-1 expression is relatively lower on normal hematopoietic stem cells is minimal, making it an ideal anti-leukemic target. NC525, a humanized LAIR-1 mAb, targets and destroys AML blasts and LSCs. The Phase 1 study is an open-label, non-randomized, dose escalation trial to determine safety and tolerability of NC525 in adult patients with relapsed or refractory AML.
Details of the poster presentation are as follows:
Title: A Phase 1, Open-Label, Safety, Tolerability, and Efficacy Study of NC525 in Subjects with Advanced Myeloid Neoplasms
Abstract Number: 4088
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About NextCure, Inc.
NextCure is a clinical-stage biopharmaceutical company committed to discovering and developing novel, first-in-class immunomedicines to treat cancer and other immune-related diseases. Through our proprietary FIND-IO™ platform, we study various immune cells to discover and understand targets and structural components of immune cells and their functional impact in disease in order to develop immunomedicines. Our initial focus is to bring hope and new treatments to patients who do not respond to current cancer therapies, patients whose cancer progresses despite treatment and patients with cancer types not adequately addressed by available therapies. http://www.nextcure.com
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Source: NextCure