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Date:
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| | June 22, 2023 | | |
Record Date:
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| | April 24, 2023 | | |
| | Time: | | |
10:00 a.m. ET
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| | Attendance: | | |
www.virtualshareholdermeeting.com/NXTC2023
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Proposals
|
| |
Board Vote
Recommendation |
| |
Page
|
|
1.
Elect the three Class I director nominees named in this Proxy Statement
|
| | FOR each nominee | | | | |
2.
Ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ended December 31, 2023
|
| | FOR | | | |
Board Diversity Matrix
|
| ||||||||||||
Total Number of Directors: 9
|
| ||||||||||||
| | |
Female
|
| |
Male
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| ||||||
Directors | | | | | 3 | | | | | | 6 | | |
Asian
|
| | | | — | | | | | | 1 | | |
White
|
| | | | 3 | | | | | | 5 | | |
| |
OUR BOARD UNANIMOUSLY RECOMMENDS A VOTE
“FOR” EACH OF THE CLASS I DIRECTOR NOMINEES LISTED BELOW. |
| |
| |
Independent
Director Since: October 2021
Committee Service:
•
Nominating and Governance Committee
Age: 55
Other Public Boards:
•
Curis, Inc.
|
| | |
Experience and Expertise
Dr. Borgman is currently serves as the Chief Medical Officer of Sutro Biopharma, Inc., a biotechnology company, which is a position she started in February 2023. Before taking that role, Dr. Borgman was the Principal of AEB Hematology Oncology Development Consulting, a position held from November 2021 to February 2023, where she provided strategic and tactical/operational clinical development consulting. Previously, Dr. Borgman served as Vice President and Global Therapeutic Area Lead, Hematology-Oncology of Jazz Pharmaceuticals plc, a global biopharmaceutical company, from 2019 to 2021. Prior to joining Jazz Pharmaceuticals, she served as Vice President, Clinical Research & Development at Exelixis Biopharmaceuticals, Inc. from 2012 to 2019, and has previously served as Global Therapeutic Area Head Oncology at Abbott Laboratories, and as Chief Medical Officer for biotech companies in the Bay Area. Dr. Borgman currently serves on the board of directors at Curis, Inc., a public biotechnology company focused on the development of therapeutics for the treatment of cancer, and NiKang Therapeutics Inc., a private clinical stage biotechnology company focused on developing small molecule oncology medicines. Dr. Borgman completed her clinical and research fellowship at the University of California, Los Angeles, Section of Pediatric Hematology Oncology and Bone Marrow Transplant, and prior to that completed her pediatric residency at Baylor College of Medicine/Texas Children’s Hospital. Dr. Borgman received her Bachelor of Science in Biochemistry from the University of Illinois and received her M.D. from the Loyola University of Chicago Stritch School of Medicine. Dr. Borgman is licensed to practice medicine in the states of California and Illinois. Dr. Borgman held an adjunct faculty member position at Stanford University School of Medicine, Department of Pediatrics, Division of Hematology, Oncology, Stem Cell, Transplantation, and Cancer Biology and formerly was an Attending Clinical Associate at the University of Chicago, Department of Pediatric Oncology and Stem Cell Research.
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| |
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Qualifications
•
Extensive experience in the pharmaceutical industry as a senior executive and director
•
Extensive experience in oncological drug development, clinical research and trials
|
| |
| |
Independent
Director Since: September 2020
Committee Service:
•
Nominating and Governance Committee
Age: 63
Other Public Boards:
•
Arvinas Inc.
|
| | |
Experience and Expertise
Dr. Houston has served as President and Chief Executive Officer of Arvinas Inc., a clinical-stage biotechnology company, and as a member of its board of directors since September 2017. He previously served as Arvinas’ President of Research Development and Chief Scientific Officer from January 2017 to September 2017. Dr. Houston also currently serves as a director of several privately held companies, including Oerth Bio LLC, Cybrexa, Inc. and Connecticut United for Research Excellence Inc (also known as BioCT). Prior to joining Arvinas, he spent more than 18 years at Bristol Myers Squibb Company (“BMS”) in roles of increasing responsibility and had accountability for all Discovery Biology disease teams, as well as various Discovery technology departments. He was the senior vice president of Specialty Discovery and R&D Site Development at BMS from September 2015 to August 2016 and previously worked in various roles across BMS’ Discovery Biology, Applied Biotechnology and Early Discovery Chemistry departments. While at BMS Dr. Houston was a member of the BMS senior executive leadership team, which reviewed and approved over 200 pre-clinical candidates for progression into early development, several of which advanced into late-stage clinical trials, and toward commercialization. He was also the principal architect and driver of the “Leveraging Technology” initiative at BMS, which led to an industry-leading integrated lead discovery and optimization process. Prior to joining BMS, he worked at Glaxo Welcome Research and Development in the United Kingdom, where he served as head of the Lead Discovery Unit. Dr. Houston obtained a B.Sc. in Medical Microbiology from Glasgow University and a Ph.D. in Microbial Biochemistry from Heriot-Watt University, Edinburgh.
|
| |
|
Qualifications
•
Extensive experience in the pharmaceutical industry as a senior executive and director
•
Service on the boards of other public and private biopharmaceutical and biotechnology companies
|
| |
| |
Independent
Director Since: March 2021
Committee Service:
•
Audit Committee
Age: 68
Other Public Boards:
•
G1 Therapeutics, Inc.
•
Day One Biopharmaceuticals, Inc.
|
| | |
Experience and Expertise
Mr. Nicholson is currently retired, but has served as a member of the board of directors of publicly traded biopharmaceutical companies G1 Therapeutics, Inc. since September 2018 (including as chairman since June 2019), and Day One Biopharmaceuticals, Inc. since September 2022. Mr. Nicholson also previously served on the board of directors of publicly traded biopharmaceutical company Turning Point Therapeutics, Inc. from January 2020 until its acquisition by BMS in April 2022, Five Prime Therapeutics, Inc. from May 2017 until its acquisition by Amgen Inc. in April 2021, and TESARO, Inc. from May 2015 until its acquisition by GlaxoSmithKline plc in January 2019. Prior to his retirement, Mr. Nicholson served as President and Chief Executive Officer of XTuit Pharmaceuticals, Inc., a biopharmaceutical company, from September 2015 to October 2016. Prior to that, he led the oncology business at Pfizer from May 2008 until he departed in March 2015 as President, Oncology, during which he oversaw global commercialization and sales, clinical development, regulatory and business strategies. In addition to his oncology role, he was a member of Pfizer Inc.’s Portfolio Strategy and Investment Committee, the governance body with oversight responsibility for the company’s research and development. Prior to joining Pfizer, Mr. Nicholson worked in the oncology division of Eli Lilly and Company, where he held a number of leadership roles. Mr. Nicholson received a B.S. in pharmacy from the University of North Carolina, Chapel Hill, and an M.B.A. from the University of South Carolina, Columbia.
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| |
|
Qualifications
•
Extensive experience in the pharmaceutical industry as a senior executive and director
•
Service on the boards of other public and private biopharmaceutical and biotechnology companies
|
| |
| |
Independent
Director Since: December 2015
Committee Service:
•
Nominating and Corporate Governance Committee (Chair)
Age: 68
Other Public Boards:
•
CytomX Therapeutics, Inc.
•
Gritstone Oncology, Inc.
•
HBM Healthcare Investments Ltd.
|
| | |
Experience and Expertise
Dr. Jones served as Vice President, Worldwide Business Development and Senior Partner at Pfizer Ventures, a life sciences investment company, where she was responsible for making and managing venture investments of strategic interest to Pfizer Inc., from December 2008 to April 2019. Prior to joining Pfizer, Dr. Jones was a General Partner with EuclidSR Partners. She began her private equity career in 1999 at S.R. One, GlaxoSmithKline’s venture fund. Before that, she was Director of Scientific Licensing for SmithKline Beecham and a research scientist for SmithKline Beecham Pharmaceutical R&D. Dr. Jones has served on the board of directors of publicly traded CytomX Therapeutics, Inc., a clinical-stage biopharmaceutical company, since May 2019 (she also previously served on CytomX’s board from December 2014 to June 2016), Gritstone Oncology, Inc., an immuno-oncology company, since September 2019, and HBM Healthcare Investments Ltd., a healthcare investment portfolio company, since June 2021. She also served on the board of Ibere Pharmaceuticals from February 2021 to March 2023. Dr. Jones currently serves on the board of directors for various privately held companies, including Mironid Ltd. and Myeloid Therapeutics, Inc., and as a trustee of Juniata College. Dr. Jones previously served on the boards of directors of several publicly traded healthcare companies, including Mersana Therapeutics, Inc. from February 2015 to June 2018, Mirna Therapeutics, Inc. from December 2012 to June 2016, Aquinox Pharmaceuticals, Inc. from June 2010 to February 2015 and Flexion Therapeutics, Inc. from December 2009 to June 2014. Dr. Jones received a B.S. in biology from Juniata College and a Ph.D. in microbiology from the University of Pittsburgh.
|
| |
|
Qualifications
•
Background in scientific and pharmaceutical industry
•
Extensive experience in the venture capital industry
|
| |
| |
Independent
Director Since: December 2015
Committee Service:
•
Compensation Committee (Chair)
Age: 47
Other Public Boards:
•
Fusion Pharmaceuticals Inc.
•
Galecto, Inc.
|
| | |
Experience and Expertise
Mr. Khuong is a biotechnology investor and entrepreneur. Mr. Khoung previously served as a Partner at OrbiMed Advisors LLC, an investment firm, from 2003 until March 2022, where he was a member of the investment committee for the firm’s venture capital funds. Mr. Khuong currently serves as a director of two other publicly traded companies, Fusion Pharmaceuticals Inc. since 2019 and Galecto, Inc. since 2020, as well as several privately held companies, including OnCusp Therapeutics Inc. and NextPoint Therapeutics, Inc. Mr. Khuong formerly served as a director of various other private and public companies, including publicly traded Synlogic, Inc., BELLUS Health Inc., Inspire Medical Systems, Inc., Aerpio Pharmaceuticals, Inc., Nabriva Therapeutics plc (formerly Nabriva Therapeutics AG), Otonomy, Inc. and Pieris Pharmaceuticals, Inc. Mr. Khuong holds a B.S. in molecular, cellular and development biology and a M.P.H. with a concentration in infectious diseases, both from Yale University.
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| |
|
Qualifications
•
Service on the boards of other public and private companies
•
Extensive experience investing in healthcare companies
|
| |
| |
Independent
Director Since: October 2021
Committee Service:
•
Compensation Committee
Age: 68
Other Public Boards:
•
Xencor, Inc.
|
| | |
Experience and Expertise
Dr. Feigal has served as a Partner and Head of the Biologics Practice at NDA Partners LLC since 2014. NDA Partners is part of ProPharma Group, a life sciences management consulting and contract development organization. Dr. Feigal also currently serves as a board member for Xencor, Inc. Dr. Feigal was formerly Senior Vice President of Research and Development at the California Institute for Regenerative Medicine; Executive Medical Director, Global Development, at Amgen; Chief Medical Officer at Insys Therapeutics, and a Founding Director of the American Course on Drug Development and Regulatory Sciences at the University of California, San Francisco (UCSF). Prior to her position at UCSF, Dr. Feigal was Director of Medical Devices and Imaging at the Critical Path Institute and Vice President of Clinical Sciences at the Translational Genomics Research Institute. Dr. Feigal received her M.D. from the University of California, Davis and completed an internal medicine residency at Stanford University and a hematology/oncology fellowship at University of California, San Francisco, and currently serves as an adjunct professor at Arizona State University Sandra Day O’Connor College of Law.
|
| |
|
Qualifications
•
Service on the boards of other public and private companies
•
Extensive experience in the pharmaceutical industry as a senior executive and director
|
| |
| |
Independent
Director Since: December 2015
Committee Service:
•
Audit Committee
•
Compensation Committee
Age: 75
|
| | |
Experience and Expertise
Dr. Kabakoff has served as Executive Partner at Sofinnova Investments, Inc., a clinical-stage biopharmaceutical venture capital firm, since May 2007 and became a founding Partner of HealthQuest Capital, a health care innovation venture capital firm, in 2012. Dr. Kabakoff currently serves on the board of directors of several privately-held life sciences companies, including RareCyte, Inc. and Antiva Biosciences, Inc. Dr. Kabakoff previously served as a director of several other publicly traded and privately held life sciences companies, including Castle Biosciences, Inc. from September 2017 to August 2021, Principia Biopharma, Inc. from June 2016 to August 2018 in advance of Principia’s September 2018 initial public offering, publicly traded lnterMune, Inc. from November 2005 to September 2014, and Amplimmune from 2007 until its acquisition by AstraZeneca plc in October 2013. In 2001, Dr. Kabakoff co-founded Salmedix, Inc., a company that developed cancer drug treatments, served as the company’s Chairman and Chief Executive Officer and led its acquisition in June 2005 by Cephalon, Inc. Previously, Dr. Kabakoff served as Executive Vice President of Dura Pharmaceuticals, Inc., a pharmaceutical company, as President and Chief Executive Officer of Spiros, a pharmaceutical company, as Chief Executive Officer of Corvas International, Inc., a developer of biotherapeutics, and in senior executive positions with Hybritech, a biotechnology company. Dr. Kabakoff received a B.A. in chemistry from Case Western Reserve University and a Ph.D. in chemistry from Yale University.
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| |
|
Qualifications
•
Extensive experience in the biotechnology industry
•
Extensive experience in the venture capital industry
|
| |
| |
Director Since: October 2015
Age: 62
Other Public Boards:
•
Pieris Pharmaceuticals, Inc.
|
| | |
Experience and Expertise
Mr. Richman co-founded our company and has served as our President, Chief Executive Officer and a member of the Board since October 2015. Mr. Richman served as President and Chief Executive Officer of Amplimmune, Inc. (now MedImmune, LLC), a biopharmaceutical company focused on immuno-oncology, from 2007 to August 2015, including through Amplimmune’s acquisition by AstraZeneca plc in October 2013. Before Amplimmune, Mr. Richman served as Executive Vice President and Chief Operating Officer of MacroGenics, Inc., a biopharmaceutical company focused on the treatment of cancer, from 2002 to 2007. Mr. Richman joined MacroGenics with approximately 20 years’ experience in corporate business development within the biotechnology industry. Mr. Richman has served as a director of publicly traded Pieris Pharmaceuticals, Inc., a clinical-stage biotechnology company, since December 2014, and as a director of Madison Vaccines, Inc., a private company, since May 2014. Mr. Richman was previously a member of the board of directors of GenVec, Inc. from April 2015 until its acquisition by Intrexon Corporation in June 2017 and Opexa Therapeutics, Inc. from June 2006 until its acquisition by Acer Therapeutics in September 2017. Mr. Richman received a B.S. in genetics and molecular biology from the University of California at Davis and an M.S.B.A. in international business from San Francisco State University.
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| |
|
Qualifications
•
Service as our President and Chief Executive Officer
•
Service on the boards of other private and public life sciences companies
•
Extensive knowledge of our company and industry, including comprehensive experience in financing, corporate management, research and business development
|
| |
| |
Independent
Director Since: April 2019
Committee Service:
•
Audit Committee (Chair)
Age: 62
Other Public Boards:
•
Cullinan Oncology, Inc.
•
Nabriva Therapeutics AG
•
TCR2 Therapeutics Inc.
|
| | |
Experience and Expertise
Mr. Webster served as the Chief Financial Officer of Spark Therapeutics, Inc., a publicly traded biotechnology company, from July 2014 until its acquisition by Roche in December 2019. He currently serves as a director of several publicly traded life sciences companies, including TCR2 Therapeutics Inc., since May 2020, Nabriva Therapeutics AG (formerly Nabriva Therapeutics plc), since August 2016, and Cullinan Oncology, Inc., since October 2020. Mr. Webster previously served on the board of directors of Viking Therapeutics, Inc. Mr. Webster was also previously Senior Vice President and Chief Financial Officer of Optimer Pharmaceuticals, Inc. (“Optimer”), a publicly traded biotechnology company, from July 2012 until its acquisition by Cubist Pharmaceuticals, Inc. in October 2013. Prior to joining Optimer, Mr. Webster served as SVP and Chief Financial Officer of Adolor Corporation, a biopharmaceutical company, from 2008 until its acquisition by Cubist Pharmaceuticals, Inc. in 2011. From 2007 until joining Adolor Corporation in 2008, Mr. Webster served as Managing Director, Investment Banking Division, Health Care Group for Broadpoint Capital Inc. (formerly First Albany Capital). Mr. Webster served as co-founder, President and Chief Executive Officer for Neuronyx, Inc., a biopharmaceutical company, from 2000 to 2006. Mr. Webster previously served in positions of increased responsibility, including as Director, Investment Banking Division, Health Care Group for PaineWebber Incorporated. Mr. Webster received an A.B. in economics from Dartmouth College and an M.B.A. in finance from The Wharton School of the University of Pennsylvania.
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| |
|
Qualifications
•
Extensive experience in the biopharmaceutical industry
•
Service as chief financial officer and on the boards of other public companies
|
| |
| | | | | | | | | | | | | | | | | | | | |
Committee Memberships
|
| |||||||||||||||
Name
|
| |
Age
|
| |
Director
Since |
| |
Independent
|
| |
Audit
|
| |
Compensation
|
| |
Nominating and
Corporate Governance |
| ||||||||||||||||||
Anne Borgman, M.D. | | | | | 55 | | | | | | 2021 | | | | | | ✔ | | | | | | | | | | | | | | | | | | ✔ | | |
Ellen G. Feigal, M.D. | | | | | 68 | | | | | | 2021 | | | | | | ✔ | | | | | | | | | | | | ✔ | | | | | | | | |
John G. Houston, Ph.D. | | | | | 63 | | | | | | 2020 | | | | | | ✔ | | | | | | | | | | | | ✔ | | | | | | | | |
Elaine V. Jones, Ph.D. | | | | | 68 | | | | | | 2015 | | | | | | ✔ | | | | | | | | | | | | | | | | | | © | | |
David Kabakoff, Ph.D. | | | | | 75 | | | | | | 2015 | | | | | | ✔ | | | | | | ✔ | | | | | | | | | | | | ✔ | | |
Chau Q. Khuong | | | | | 47 | | | | | | 2015 | | | | | | ✔ | | | | | | | | | | | | © | | | | | | | | |
Garry A. Nicholson | | | | | 68 | | | | | | 2020 | | | | | | ✔ | | | | | | ✔ | | | | | | | | | | | | | | |
Michael Richman | | | | | 62 | | | | | | 2015 | | | | | | | | | | | | | | | | | | | | | | | | | | |
Stephen W. Webster | | | | | 62 | | | | | | 2019 | | | | | | ✔ | | | | | | © | | | | | | | | | | | | | | |
2022 Meetings
|
| | | | | | | | | | | | | |
Board: 6
|
| | | | 4 | | | | | | 4 | | | | | | 4 | | |
|
Name
|
| |
Fees Earned
or Paid in Cash ($) |
| |
Option Awards
($)(1) |
| |
All Other
Compensation ($) |
| |
Total
($) |
| ||||||||||||
| David Kabakoff, Ph.D. | | | | | 76,500 | | | | | | 46,170 | | | | | | — | | | | | | 122,670 | | |
| Anne Borgman, M.D. | | | | | 44,000 | | | | | | 46,170 | | | | | | — | | | | | | 90,170 | | |
| Ellen Feigal, M.D. | | | | | 45,000 | | | | | | 46,170 | | | | | | — | | | | | | 91,170 | | |
| John G. Houston, Ph.D. | | | | | 45,000 | | | | | | 46,170 | | | | | | — | | | | | | 91,170 | | |
| Elaine V. Jones, Ph.D. | | | | | 48,000 | | | | | | 46,170 | | | | | | — | | | | | | 94,170 | | |
| Chau Q. Khuong | | | | | 50,000 | | | | | | 46,170 | | | | | | — | | | | | | 96,170 | | |
| Garry A. Nicholson | | | | | 47,500 | | | | | | 46,170 | | | | | | — | | | | | | 93,670 | | |
| Stephen W. Webster | | | | | 55,000 | | | | | | 46,170 | | | | | | — | | | | | | 101,170 | | |
|
Name
|
| |
Options
Outstanding (#) |
| |||
| David Kabakoff, Ph.D. | | | | | 102,092 | | |
| Anne Borgman, M.D. | | | | | 53,134 | | |
| Ellen Feigal, M.D. | | | | | 53,134 | | |
| John G. Houston, Ph.D. | | | | | 67,687 | | |
| Elaine V. Jones, Ph.D. | | | | | 64,750 | | |
| Chau Q. Khuong | | | | | 64,750 | | |
| Garry A. Nicholson | | | | | 73,083 | | |
| Stephen Webster | | | | | 64,750 | | |
| |
OUR BOARD AND AUDIT COMMITTEE UNANIMOUSLY RECOMMEND A VOTE
“FOR” THE RATIFICATION OF THE APPOINTMENT OF ERNST & YOUNG LLP AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR THE FISCAL YEAR ENDING DECEMBER 31, 2023. |
| |
Fee Category
|
| |
2022
|
| |
2021
|
| ||||||
Audit Fees | | | | $ | 787,773 | | | | | $ | 760,840 | | |
Audit-Related Fees | | | | | — | | | | | | — | | |
Tax Fees | | | | $ | 40,425 | | | | | $ | 45,755 | | |
All Other Fees | | | | $ | 2,120 | | | | | $ | 2,000 | | |
Total Fees | | | | $ | 830,318 | | | | | $ | 808,595 | | |
| |
The primary function of the audit committee is to oversee our accounting and financial reporting processes and the external audit of our financial statements on behalf of the Board. The audit committee operates under a written charter adopted by the Board that satisfies applicable SEC and Nasdaq standards and is available in the “Investors — Governance” section of our corporate website, www.nextcure.com. The audit committee reviews the charter and proposes necessary changes to the Board on an annual basis.
The audit committee has reviewed and discussed with management our audited financial statements for the fiscal year ended December 31, 2022 and has discussed with EY, our independent registered public accounting firm for the fiscal year ended December 31, 2022, the matters required to be discussed by the applicable requirements of the Public Company Accounting Oversight Board (the “PCAOB”) and the SEC. The audit committee has also received the written disclosures and the letter from EY required under the applicable requirements of the PCAOB regarding EY’s communications with the audit committee concerning independence and discussed with EY its independence.
On the basis of the review and discussions referenced above, the audit committee recommended to the Board that the audited financial statements be included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2022 for filing with the SEC.
In addition to its oversight of our corporate accounting and financial reporting process, the audit committee is responsible for the appointment, oversight, evaluation, and retention of our independent registered public accounting firm. In connection with this responsibility, the audit committee annually reviews the qualifications, performance, and independence of the independent registered public accounting firm, including the performance of the lead audit partner, and assures the regular rotation of the lead audit partner as required. In doing so, the audit committee considers a number of factors including, but not limited to, quality of services provided, technical expertise, knowledge of the industry, effective communication, and objectivity. The audit committee also considers whether the non-audit services provided by the independent registered public accounting firm are compatible with maintaining its independence.
The audit committee has engaged EY as our independent registered public accounting firm for the fiscal year ending December 31, 2023, and is seeking ratification of such engagement by our stockholders.
Audit Committee
Stephen Webster, Chair
David Kabakoff, Ph.D. Garry A. Nicholson |
| |
Name
|
| |
Position
|
| |
Age
|
|
Michael Richman | | | President and Chief Executive Officer | | |
62
|
|
Steven P. Cobourn, CPA | | | Chief Financial Officer | | |
60
|
|
Dr. Han Myint, MD, FACP | | | Chief Medical Officer | | |
70
|
|
Sol Langermann, Ph.D. | | | Chief Scientific Officer | | |
63
|
|
Timothy Mayer, Ph.D. | | | Chief Operating Officer | | |
58
|
|
Sourav Kundu, Ph.D. | | | Senior Vice President, Development & Manufacturing | | |
63
|
|
Kevin G. Shaw | | | Senior Vice President, Legal Affairs | | |
49
|
|
Name and principal position
|
| |
Year
|
| |
Salary
($) |
| |
Bonus
($) |
| |
Option
Awards ($)(1) |
| |
Non-Equity
Incentive Plan Compensation ($) |
| |
All Other
Compensation ($)(2) |
| |
Total
($) |
| |||||||||||||||||||||
Michael Richman
President and Chief Executive Officer |
| | | | 2022 | | | | | | 549,375 | | | | | | — | | | | | | 1,010,240 | | | | | | 151,300 | | | | | | 13,271 | | | | | | 1,724,186 | | |
| | | 2021 | | | | | | 529,167 | | | | | | — | | | | | | 2,595,000 | | | | | | 194,300 | | | | | | 2,958 | | | | | | 3,321,425 | | | ||
Han Myint, M.D., FACP
Chief Medical Officer |
| | | | 2022 | | | | | | 445,413 | | | | | | — | | | | | | 398,860 | | | | | | 98,200 | | | | | | 10,845 | | | | | | 953,318 | | |
| | | 2021 | | | | | | 415,341 | | | | | | 75,000(3) | | | | | | 1,650,000 | | | | | | 119,600 | | | | | | 2,041 | | | | | | 2,261,982 | | | ||
Sol Langermann, Ph.D.
Chief Scientific Officer |
| | | | 2022 | | | | | | 432,242 | | | | | | — | | | | | | 451,900 | | | | | | 95,300 | | | | | | 11,082 | | | | | | 990,524 | | |
| | | 2021 | | | | | | 406,350 | | | | | | — | | | | | | 865,000 | | | | | | 119,700 | | | | | | 1,932 | | | | | | 1,392,982 | | |
| | |
Option Awards
|
| |||||||||||||||||||||
Name
|
| |
Number of Securities
Underlying Unexercised Options (#) Exercisable |
| |
Number of Securities
Underlying Unexercised Options (#) Unexercisable |
| |
Option
Exercise Price ($) |
| |
Option
Expiration Date |
| ||||||||||||
Michael Richman
|
| | | | 99,579 | | | | | | — | | | | | | 1.21 | | | | | | 3/14/2027 | | |
| | | 118,249 | | | | | | — | | | | | | 1.77 | | | | | | 8/26/2028 | | | ||
| | | 373,422 | | | | | | — | | | | | | 7.63 | | | | | | 12/20/2028 | | | ||
| | | 159,374 | | | | | | 65,626(1) | | | | | | 41.76 | | | | | | 2/27/2030 | | | ||
| | | 131,250 | | | | | | 168,750(2) | | | | | | 12.59 | | | | | | 3/14/2031 | | | ||
| | | — | | | | | | 262,400(3) | | | | | | 5.57 | | | | | | 1/31/2032 | | | ||
Han Myint, M.D., FACP
|
| | | | 95,833 | | | | | | 104,167(4) | | | | | | 12.09 | | | | | | 1/12/2031 | | |
| | | — | | | | | | 103,600(3) | | | | | | 5.57 | | | | | | 1/31/2032 | | | ||
Sol Langermann
|
| | | | 24,894 | | | | | | — | | | | | | 0.48 | | | | | | 8/31/2026 | | |
| | | 24,894 | | | | | | — | | | | | | 1.21 | | | | | | 3/14/2027 | | | ||
| | | 24,894 | | | | | | — | | | | | | 1.77 | | | | | | 8/26/2028 | | | ||
| | | 87,131 | | | | | | — | | | | | | 7.63 | | | | | | 12/20/2028 | | | ||
| | | 55,391 | | | | | | 22,809(1) | | | | | | 41.76 | | | | | | 2/27/2030 | | | ||
| | | 43,750 | | | | | | 56,250(2) | | | | | | 12.59 | | | | | | 3/14/2031 | | | ||
| | | — | | | | | | 117,400(3) | | | | | | 5.57 | | | | | | 1/13/2032 | | |
| | |
Number of Shares to be
Issued upon Exercise of Outstanding Options, Warrants and Rights (#) |
| |
Weighted Average
Exercise Price of Outstanding Options, Warrants and Rights ($) |
| |
Number of Securities
Remaining Available for Future Issuance Under Equity Compensation Plans (Excluding Securities Reflected in Column (a)) (#) |
| |||||||||
Equity Compensation plans
approved by security holders |
| | | | 5,262,179(1) | | | | | $ | 11.44 | | | | | | 3,394,964(2) | | |
Equity Compensation plans not
approved by security holders |
| | | | — | | | | | | — | | | | | | — | | |
Total
|
| | | | 5,262,179 | | | | | $ | 11.44 | | | | | | 3,394,964 | | |
Name of Beneficial Owner
|
| |
Number of
Shares Beneficially Owned (#) |
| |
Percentage of
Shares Beneficially Owned (%) |
| ||||||
5% Stockholders: | | | | | | | | | | | | | |
OrbiMed Advisors LLC(2) | | | | | 2,711,013 | | | | | | 9.7% | | |
Sofinnova Venture Partners IX, L.P.(3) | | | | | 2,671,856 | | | | | | 9.6% | | |
Pfizer Inc.(4) | | | | | 1,970,759 | | | | | | 7.1% | | |
Millennium Group Management LLC(1) | | | | | 1,449,885 | | | | | | 5.2% | | |
Named Executive Officers and Directors: | | | | | | | | | | | | | |
Michael Richman(5) | | | | | 1,426,603 | | | | | | 5.1% | | |
Anne Borgman, M.D.(6) | | | | | 34,134 | | | | | | * | | |
Ellen Feigal, M.D.(7) | | | | | 34,134 | | | | | | * | | |
John G. Houston, Ph.D.(8) | | | | | 58,187 | | | | | | * | | |
Elaine V. Jones, Ph.D.(9) | | | | | 64,750 | | | | | | * | | |
David Kabakoff, Ph.D.(10) | | | | | 164,329 | | | | | | * | | |
Chau Q. Khuong(11) | | | | | 64,750 | | | | | | * | | |
Sol Langermann, Ph.D.(12) | | | | | 358,075 | | | | | | 1.3% | | |
Han Myint, M.D., FACP(13) | | | | | 155,366 | | | | | | * | | |
Garry Nicholson(14) | | | | | 73,083 | | | | | | * | | |
Stephen W. Webster(15) | | | | | 64,750 | | | | | | * | | |
All executive officers and directors as a group (15 persons)(16)
|
| | | | 3,304,826 | | | | | | 11.9% | | |